In recent years, computer hardware and software development has followed a trend of optimizing for efficiency for common use cases while neglecting potential side effects and their security implications. My research aims to better understand the threat posed by these side effects, from exploiting bit-flips in physical memory, to leveraging speculative side-channels and manipulating a victim's operation system. Through my research, I have developed novel attacks focuses on various targets across the computer architecture stack with the goal of better understanding what exploits are possible in the hopes of building more secure defenses.